I tried giving 3 capsules at bedtime and again first thing in the morning to my husband for his constipation issues several years ago and it didn't help him at all! BUT, last month he followed the Colon Cleanse plan very closely, with the herbs, Flora-Key the 2nd half and the diet for 5 weeks. I started giving him the Super-GI during the 1st two weeks of the Colon Cleanse, and he started having a good bowel movement every day. Now 2 weeks after the cleanse, and taking the Super-GI twice a day plus following a good diet, he is still quite regular. The first time he has been in all of his 66 years! As a retired Colon Therapist, I am thrilled.